OA08.04. Brain circuitry subserving acupuncture relief of itch in atopic dermatitis: an fMRI study
نویسندگان
چکیده
Purpose Chronic itch is a prevalent symptom of many inflammatory skin disorders, including atopic dermatitis (AD). While conventional systemic approaches to reduce AD itch have shown limited efficacy and/or significant side effects, several recent studies have demonstrated effectiveness of acupuncture for reducing itch in healthy adults and AD. We sought to evaluate the brain circuitry underlying acupuncture reduction of itch.
منابع مشابه
The brain circuitry mediating antipruritic effects of acupuncture.
Itch is an aversive sensory experience and while systemic therapies, such as acupuncture, have shown promise in alleviating itch in patients suffering from chronic itch, their antipruritic mechanisms are unknown. As several lines of evidence implicate brain-focused mechanisms, we applied functional magnetic resonance imaging and our validated temperature-modulation itch model to evaluate the un...
متن کاملThe imagined itch: brain circuitry supporting nocebo-induced itch in atopic dermatitis patients.
BACKGROUND Psychological factors are known to significantly modulate itch in patients suffering from chronic itch. Itch is also highly susceptible to both placebo and nocebo (negative placebo) effects. Brain activity likely supports nocebo-induced itch, but is currently unknown. METHODS We collected functional MRI (fMRI) data from atopic dermatitis (AD) patients, in a within-subject design, a...
متن کاملAcupuncture compared with oral antihistamine for type I hypersensitivity itch and skin response in adults with atopic dermatitis: a patient- and examiner-blinded, randomized, placebo-controlled, crossover trial.
BACKGROUND Itch is the major symptom of atopic dermatitis (AD). Acupuncture has been shown to exhibit a significant effect on experimental itch in AD. Our study evaluated acupuncture and antihistamine itch therapy (cetirizine) on type I hypersensitivity itch and skin reaction in AD using a patient and examiner-blinded, randomized, placebo-controlled, crossover trial. METHODS Allergen-induced ...
متن کاملBrain Processing of Contagious Itch in Patients with Atopic Dermatitis
Several studies show that itch and scratching cannot only be induced by pruritogens like histamine or cowhage, but also by the presentation of certain (audio-) visual stimuli like pictures on crawling insects or videos showing other people scratching. This phenomenon is coined "Contagious itch" (CI). Due to the fact that CI is more profound in patients with the chronic itchy skin disease atopic...
متن کاملAntipruritic Effect of Acupuncture in Patients with Atopic Dermatitis: Feasibility Study Protocol for a Randomised, Sham-Controlled Trial
This study aims to test the feasibility of a randomised clinical trial to evaluate how acupuncture affects atopic dermatitis (AD) symptoms and quality of life and to explore potential biomarkers that may be associated with AD. It is a sham-controlled trial in which 30 eligible patients will be randomly allocated in a 1 : 1 : 1 ratio to one of three groups: verum acupuncture (VA) group 1 (3 time...
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عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2012